The show is hosted by Southern-California based Eddie "Piolin" Sotelo. So far, no reason has been given for why the show is being dropped, though the Los Angeles Times said the show had been eclipsed in the competitive market.
The show airs on dozens of radio stations in more than 20 states, and made its reputation with satirical sketches, commentary, wordplay and interjections by wacky characters.
In addition to his program's madhouse style, Sotelo used his popularity to urge his audience to turn out for immigration reform events and to push Hispanics to wield their clout in elections.
The Associated Press contributed to this report.