The incident started when the California Highway Patrol tried to stop the motorcyclist for speeding on the southbound 101 Freeway near Wendy Drive.
The motorcyclist got off the freeway, but refused to stop and led officers on a short pursuit. The rider was killed after losing control of his bike and crashing on Rancho Dos Vientos.
Authorities say he had been going about 100 mph. His identity has not been released.