According to San Bernardino County Fire officials, a pickup truck crashed into a tour bus near Zzyzx Road just after 10:30 a.m.
Authorities say it appears the truck may have crossed the median and collided with the bus.
The driver of the truck was killed and six others were injured. Five of those injured suffered minor injuries.
Traffic was backed up for miles heading to Las Vegas. Officials closed the 15 Freeway at Afton Road for several hours. Caltrans said the scene was cleared as of 7 p.m.