Between 10 p.m. Friday and 5 a.m. Monday, two lanes of the eastbound 60 will be closed from Fullerton Road to Nogales Street. The Fullerton and Nogales on-ramps and off-ramps will be closed, as well as on-ramps from Hacienda Boulevard and Azusa Avenue.
The entire eastbound side of the freeway will be closed from 1 a.m. to 5 a.m. Saturday and Monday.
Motorists are being asked to use alternate routes to avoid the weekend closures, which Caltrans has dubbed "Summer Slam."
The project involves resurfacing the 60 Freeway between the 605 and 57 freeways. Caltrans says the project should be completed next year.
City News Service contributed to this report.