The girls -- one from Missouri and the other from Louisiana -- were rescued on Friday. Deputies found them at a motel in Artesia and a home in South Los Angeles.
Investigators later tracked down and arrested the suspects, who were then booked into jail. The suspects face several charges, including conspiracy to commit human trafficking, false imprisonment and sex crimes against children. Their names have not been released.
Authorities say the teen girls are now in protective custody pending notification of their families.
City News Service contributed to this report.