The incident happened just after 4:30 p.m. in the 6200 block of Sepulveda Boulevard.
According to Los Angeles Fire Department officials, the 60-year-old woman was walking on the sidewalk when she was struck. She was transported to a local hospital in serious condition.
The driver was assessed at the scene but was uninjured.
Officials are still trying to figure out the series of events that led up to the crash.
Police say the driver lost control of the vehicle and was not cited.
The incident remains under investigation.