The 31-year-old will have a show at Planet Hollywood Resort & Casino. "Britney: Piece of Me" will debut in December.
Spears announced 16 dates but will perform 15 shows each next year and in 2015.
The Grammy-winning singer's confirmation about the residency comes months after rumors swirled online. She told "GMA" the show will feature her greatest hits as well as new material. She added that she is training five hours each day.
Tickets go on sale Friday. Prices range from $59 to $179.
Spears, who debuted on the music scene in 1999, has released seven platinum-plus albums. She has more than a dozen Top 10 hits, including "Toxic," ''Gimme More" and "Oops!... I Did It Again."
