Dozens of firefighters battled the three-alarm blaze as flames shot through the building's roof shortly before 1 a.m. Wednesday.
It took about two hours to put out the flames in the one-story structure.
Fortunately, no one was hurt.
The fire destroyed Ruby's Grill Baja Style restaurant.
The cause of the fire is under investigation. Main Street was shut down between Collins and Walnut avenues as firefighters fought the blaze.
City News Service contributed to this report.