The crash occurred on the 3900 block of Saviers Road around 1 a.m.
Police said a red 1991 Honda Civic was traveling northbound on the southbound lanes of Saviers Road from Bard Road. That's when the vehicle hit a blue 2006 BMW 325i, driven by Antonio Martinez Maya, 29, of Oxnard.
The two vehicles collided head on and the driver of the Honda died at the scene. He was the lone occupant in the Honda. His identity has been withheld pending notification of kin.
It remains unclear why the victim was traveling on the wrong side of the road way or if alcohol may have been a factor.
Maya was transported to a local hospital with minor injuries and is expected to be OK.
The investigation is ongoing. Anyone with information regarding this traffic collision was urged to contact Senior Officer Jamie Brown at (805) 385-7749.