The 28-year-old actress is the first woman to get the honor twice. She first received it in 2006. Last year's winner was Mila Kunis.
Johansson jokingly told the magazine she's "gotta hustle" and "pretty soon the roles you're offered all become mothers. Then they just sort of stop."
Johansson is engaged to former French journalist Romain Dauriac. It will be her second marriage. She split from Ryan Reynolds in 2010.
The November issue of Esquire featuring Johansson hits newsstands Oct. 15.
The Associated Press contributed to this report.