The game is the Trojans' first non-Thanksgiving/non-bowl Thursday game at the Coliseum. Classes will be in session and will operate on their normal schedule, school officials said.
The restrictions include campus buildings, parks, the Row and plazas. Tailgating at the Los Angeles Memorial Coliseum and Exposition Park is allowed as usual.
This will be the first game headed by interim coach Ed Orgeron, who was appointed Sept. 29 to replace the fired Lane Kiffin in USC's first midseason football coaching change.
Metro will begin enhanced Expo Line service at 4:30 p.m., with trains leaving every six minutes from the 7th Street/Metro and Culver City stations. Enhanced service will continue until about 75 minutes after the game ends.
The Orange County Transportation Authority will provide Metrolink Football Express train service from Oceanside and all points north to Union Station.
Several restaurants and establishments at L.A. Live will welcome USC fans. The Lawry's Carvery at L.A. Live will offer ticket holders a 10 percent discount.
City News Service contributed to this report.