The shooting occurred in front of Bossa Nova located at Formosa Avenue and Sunset Boulevard around 4 a.m.
The suspect shot one man in the chest and the other in the side. Both were transported to hospitals for treatment. One of the victims was said to be in stable condition. The other was rushed into surgery.
Police say they have detained some people for questioning, but it remains unclear if any of them are suspects.
No other details were released. The investigation is ongoing.
CNS contributed to this report.