The man was shot in broad daylight in the 6000 block of Main Street around 3:20 p.m.
Police responded to reports of gun shots fired and found the driver of a white van dead behind the wheel.
The van crashed into two other cars and a pole. Investigators say he was likely shot while driving.
No information on the suspect or motive has been released.
Anyone with information was urged to contact Los Angeles County Sheriff's Homicide Unit at (323) 890-5500.