Authorities say the accident happened just before 3 p.m. at Saticoy Street and Laurel Canyon Boulevard. The vehicle rear-ended the transit bus, which was carrying approximately 20 passengers.
The driver of the vehicle that struck the bus was declared dead at the scene. He has only been identified as an elderly man.
At least five others, including one adult and four children, were hospitalized for minor injuries.
The cause of the crash has not yet been determined, but police are investigating whether the driver of the car had some kind of medical issue because there were no skid marks.