Joplin died from a heroin overdose in a motel on Franklin Avenue on October 4, 1970 at 27.
Joplin, a legendary blues and soul singer, was inducted into the Rock and Roll Hall of Fame in 1995.
A Texas native, Joplin joined the San Francisco rock band Big Brother and the Holding Company in San Francisco in 1966. She attained fame with the group with the album "Cheap Thrills," before releasing more albums, including "Pearl," her best seller. She performed at the Monterey Pop Festival in 1967 and the Woodstock music festival in 1969.
Joplin's classic songs include "Ball and Chain," Piece of My Heart," "Summertime" and "Me and Bobby McGee," which was written by her friend singer-songwriter Kris Kristofferson.
Kristofferson played "Me and Bobby McGee" at Monday's ceremony on Hollywood Boulevard in front of the Musicians Institute. Music executive Clive Davis also attended the ceremony.
Joplin's is the 2,510th star on the Walk of Fame. Siblings Michael and Laura Joplin accepted the star on Janis's behalf.
City News Service contributed to this report.