Authorities received a tip about the marijuana cultivation in the 500 block of East Longden Avenue. A search warrant was served at about 7 a.m.
Police said about 1,300 marijuana plants were found in various stages of growth throughout the home.
The grow consisted of multiple rooms with irrigation, lighting, ventilation and electrical wiring.
No arrests have been made yet. Anyone with information about the case is urged to call the Arcadia Police Department at (626) 574-5150.