A female called authorities at 7:21 a.m. to report she found a skull in the desert area near South Street and Sheep Creek Road in Phelan.
No other bones were immediately found.
Sheriff's deputies closed off the area during the investigation.
The site was located about 18 miles west of Victorville.
Anyone with information regarding this investigation is urged to contact Sheriff's Homicide Detail at (909) 387-3589. Callers wishing to remain anonymous are urged to call the We-tip Hotline at (800) 78-CRIME.