The crash happened around 8:50 a.m. in the 4600 block of Los Feliz Boulevard.
Detectives say a man riding a Kawasaki motorcycle was traveling westbound, when the driver of a BMW drove out of her driveway in front of the path of the motorcyclist. The collision caused the motorcycle rider to be ejected.
The motorcyclist suffered severe head and body injuries. He was transported to a local hospital where he was later pronounced dead. His name was being withheld pending notification of next of kin.
The driver of the BMW was also transported to a nearby hospital. She suffered cuts and complained of pain to her left shoulder.
Investigators don't believe drugs or alcohol were involved.
Anyone with information about this case was asked to contact LAPD Central Traffic detectives at (213) 972-1825.