The incident occurred at the Observatory located in the 3500 block of South Harbor Boulevard around 9:30 p.m.
A 19-year-old was treated at the scene for a stab wound to his shoulder.
A second victim, identified as a 22-year-old man, suffered stab wounds to his back. He was transported by ambulance to a hospital and is said to be listed in stable condition.
Police believe the victims were randomly targeted since they did not know each other.
The motive for the attack remains unclear. No arrests have been made.
Wacka Flocka Flame is an Atlanta rapper, best-known for his single "No Hands."
Anyone with information regarding the stabbings was urged to contact Santa Ana police at (714) 245-8701.