The fire erupted on the 1700 block of North Shaffer Street at about 8:45 p.m. A knockdown was declared within 45 minutes, a fire official said.
The body of a man was found in a back bedroom of the home. His name has not been released.
The cause of the fire has not been determined. A fire official said the home was very crowded with furniture and other things inside and had "hoarder-packrat conditions."
City News Service contributed to this report.