The incident happened in the 3500 block of Marmion Way around 1:50 p.m. Saturday. Police said the girl's grandfather was backing his van out of his driveway when he hit the child.
The girl had major traumatic injuries. She was transported to a local hospital, where she later died, police said.
The incident is being investigated as an accident. Anyone with information is asked to contact LAPD detectives at (213) 486-0750 or (213) 486-0766.