Metro officials say the closure will be from Moraga Drive to Ventura Boulevard on Monday, Tuesday and Wednesday, from midnight to 5 a.m.
The closure is part of the freeway widening project. Ramps will begin closing at 7 p.m. each night, and lanes will begin closing at 10 p.m.
The northbound 405 connector to the 101 Freeway will be closed during this time, as well as the following northbound onramps: Wilshire Boulevard, Sunset Boulevard, Moraga Drive, Getty Center Drive and Skirball.