Obama's trip was initially planned for October but had to be rescheduled because of the federal government shutdown.
The first lady will speak at a fundraiser in Hancock Park at the home of Philip Rosenthal, creator of "Everbody Loves Raymond." About 200 supporters are expected.
According to the Hollywood Reporter, tickets for the event start at $1,000 for the reception; $2,500 per couple for the reception and a photograph with Obama; $4,000 for a family of four for the reception and a photo; and $10,000 for the reception, a photo and admission to a roundtable discussion.
People raising $32,400 per guest will be allowed to attend all the events with Obama, plus a special "co-chair clutch," The Hollywood Reporter reported.
Obama is also scheduled to be interviewed by Ryan Seacrest for his radio show "On Air with Ryan Seacrest" to discuss how to stay fit by eating healthy, getting active and signing up for health care.
The first lady will then spend the next two days in San Francisco for two Democratic National Committee fundraisers Thursday and one for the Democratic Congressional Campaign Committee Friday.
City News Service contributed to this report.