Authorities responded to the shooting in the 11900 block of Venice Boulevard at about 2 a.m. and found two shooting victims.
One man had been shot in the back, and the other had been shot in the foot. Both were taken to an area hospital in unknown condition.
It was not yet known if the shooting was gang related. A suspect description was not immediately available.
Anyone with information is urged to call the LAPD Pacific Station at (310) 482-6334.