The site, set up by Kaiser Permanente, is located in an empty parking lot on school campus. About 500 people were expected to be vaccinated on the first day of the new site.
Raquel Bobadilla was among the first to get her shot Friday. Here son, Daniel, said it was a relief knowing his mother has been inoculated.
"We're looking forward to be able to spend more time with her. It's been tough trying to keep our distance but with the vaccine, and once we're all vaccinated, we can spend more time together," he said.
The vaccine is currently available to people who are at least 75 years old until more vaccines become available.
Doctors and staff from local hospitals explained that working with other health organizations they will be able to provide thousands of vaccinations each day.
Kaiser Permanente said it received 42,000 doses of the vaccine.
The Cal Poly Pomona site is expected to give the underserved community access to the vaccine.
The goal is to eventually get 8,000 to 10,000 people vaccinated each day at Cal Poly Pomona, but that all depends on supply.
Coronavirus vaccination site opens at convention center