The shooting happened around 1:45 p.m. on East 49th Street near Avalon Boulevard.
Police say a female teen, believed to be around 17 years old, was standing outside when a vehicle pulled up with a male and female inside.
Someone opened fire from the vehicle multiple times, hitting the girl.
The victim died at the hospital.
A possible motive has not been determined.
Police are looking for the suspects.
Anyone with information can contact LAPD anonymously at 800-222-TIPS.