Whether anyone was injured in the incident was not immediately clear.
Firefighters responded to the scene and extinguished the flames, but eastbound traffic was backed up for miles as crews worked to clean up the 25 gallons of fuel that spilled onto the freeway. Westbound lanes remained open.
By 4 p.m., the two left lanes were reopened, while the four right lanes remained closed, as well as the northbound 605 Freeway connector to the east 10 Freeway.
All lanes reopened by 6 p.m.
The cause of the crash is under investigation by the California Highway Patrol.