Kobe Bryant scored 28 points for the Lakers (21-4), including a spinning jumper from the left side of the lane that drew his team within 88-86 with 41.7 seconds left.
But Wade and Joel Anthony blocked potentially game-tying shots in the lane on the next Lakers' possession, and after Bryant's 15-foot fadeaway rimmed out as time expired, the Heat (13-12) could celebrate snapping a three-game slide.
The Lakers' previous low this season was 93 points, and their 21 turnovers represented their second-highest total of the season.
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