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The argument escalated when one woman left the home and came back with her brother. When the woman's brother asked to talk to the other woman, another man came out of the house, and gunfire broke out.
One of the men was killed, while the other was taken to the hospital.
"All I know is he got a phone call to come down here and help his sister I guess and the shooting starts," said William Hunter, the suspect's brother-in-law. "You don't need guns to take care of a situation like this, not at all. Just tragic."
An innocent driver who was coming south on G Street was also wounded in the shooting. He was hit in the head, lost control of his vehicle, slammed into a car and went up on the curb. He then plowed through a fence and into a home. He remains in extremely critical condition. Police said it is unknown if he will survive.
"The sad part of it is there was a third victim that was shot that was apparently driving by southbound in the area, caught a stray round into the head," said Sgt. Dave Dillon of the San Bernardino Police Department.
Many residents are on edge after the shooting.
"That's what kind of fears me the most because I really don't want that to be me or my family," said Marquita Williams, whose mother-in-law lives across the street from the house. "My kids, one is two and one is four months, and I don't know what I'd do if it was one of them or me, you know."
Police were still trying to identify the innocent driver of the white pick-up truck.
Hunter says he's still struggling with the thought that his brother-in-law could be partly responsible.
"I know he was very protective of his family and so forth, but I can't believe he would go out there shooting at somebody or something like that. That would be out of his character completely," said Hunter.
Anyone with information on the shooting is urged to call the San Bernardino Police Department at (909) 384-5742.