The California Highway Patrol says the vehicle rolled over and caught fire on the westbound 10 Freeway, just west of Santa Anita Avenue in El Monte at about 1:30 p.m.
Although three people, including a child, were able to get out of the car on their own, a young girl was trapped inside.
A Good Samaritan jumped into action and pulled the girl from the flames.
Two of the victims were taken to the hospital, but everyone is expected to survive.
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