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"I read The New England Journal of Medicine, obviously highly-respected, and read that it basically had a 70 percent better rate than the top medicine out there," said Keller.
"It" was a powerful cancer drug being used to treat her MS. Allison sought the treatment from her doctor even though she didn't qualify for the clinical trial.
"It kind of struck us that if we want this, we're going to have to take some risks," said Keller.
"Now, we're taking a drug that's a little bit more dangerous, potentially, and we're using it off-label," said Neurologique medical director Dr. Daniel Kantor.
Allison's doctor is one of a growing number prescribing drugs for conditions the drugs are not FDA approved to treat.
"We're allowed to do that as physicians," said Dr. Kantor.
Drugs are often prescribed off-label for children and pregnant women because they're routinely excluded from trials.
One recent study found the most common meds prescribed unsafely or ineffectively off-label were anti-depressants and anti-psychotics.
To keep yourself safe, ask your doctor if the benefits outweigh the risks and whether your insurance will cover it.
Some doctors are prescribing a cocktail of off-label drugs called Prometa to treat alcohol and drug addictions. Critics say there's no sound scientific support.
"There have only been a few published reports describing Prometa at all, and these reports are not what are called double-blind or placebo-controlled reports," said Dr. John Mendelson from the California Pacific Medical Center Research Institute.
But former addict Matt McLellan says it's helped him stay sober for a year.
"I think I'm just so blessed to have found a cure for this disease," said McLellan.
Taking risks and creating options when none seem to be left.
Some insurance companies deny coverage of off-label treatments, but in some states, they are required to for cancer or other life-threatening conditions.
If you and your doctor are trying to get coverage for an off-label treatment, experts say you should have your doctor provide the insurer with copies of peer-reviewed articles or other reliable sources that support the drug for treatment of your condition.