Four variants found linked to ovarian cancer

ROCHESTER, Minn. The findings come from a study of more than 24,000 women that spanned three continents.

Researchers found that three loci, or locations on the chromosome, had a much stronger link to susceptibility than the others, and a fourth approached "genome-wide significance," according to a news release.

These particular loci are associated with the most aggressive and common of the four main types of ovarian cancer.

Researchers say the discoveries move them a closer to individualized risk assessments for ovarian cancer.

The findings appear in Nature Genetics.

Ovarian cancer accounts for more deaths than all other gynecological cancers combined.

For more information:

http://www.mayoclinic.org/news2010-rst/5943.html

http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.668.html

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