Her traditional radio program ends Dec. 31. The "Dr. Laura" show will begin live the following Monday at 2 p.m. on Sirius XM. The show will air three hours a day, Monday through Friday.
Sirius said the show will also be available online and through mobile phone applications. Schlessinger signed a multiyear deal with the company.
Schlessinger's current show is heard by about 8 million people a day, according to the trade publication Talkers. Sirius XM has 20 million subscribers, but it's not certain how many of them will be interested in the show.
The Associated Press Contributed to this report.