Dan Aykroyd and Justin Timberlake's animated adventure "Yogi Bear" took in a picnic basket of $16.7 million to debut at No.2.
"The Chronicles of Narnia: The Voyage of the Dawn Treader," came in third with $12.4 million.
"The Fighter," and "The Tourist" round out the top five.
1. "TRON: Legacy," $43.6 million.
2. "Yogi Bear," $16.7 million.
3. "The Chronicles of Narnia: The Voyage of the Dawn Treader," $12.4 million.
4. "The Fighter," $12.2 million.
5. "The Tourist," $8.7 million.
6. "Tangled," $8.68 million.
7. "Black Swan," $8.3 million.
8. "How Do You Know," $7.6 million.
9. "Harry Potter and the Deathly Hallows: Part 1," $4.8 million.
10. "Unstoppable," $1.8 million.
The Associated Press contributed to this report.