The animated comedy "Hop" enjoyed the No. 1 spot for the second weekend in a row with $21.7 million. "Arthur" came in at No. 2 with $12.6 million.
The Warner Bros. remake of Dudley Moore's 1981 romance stars Brand as a rich, drunken man-child who finally learns to grow up with the help of his butler, played by Helen Mirren.
Opening close behind at No. 3 with $12.3 million was Focus Features' "Hanna," the tale of a teenager trained as a killing machine that stars Cate Blanchett, Eric Bana and Saoirse Ronan.
"Soul Surfer" debuted at No. 4 with $11.1 million. The movie follows the true story of a surfer who lost an arm in a shark attack. Rounding out the top five was horror film, "Insidious," starring Patrick Wilson and Rose Byrne.
1. "Hop," $21.7 million.
2. "Arthur," $12.6 million.
3. "Hanna," $12.3 million.
4. "Soul Surfer," $11.1 million.
5. "Insidious," $9.7 million.
6. "Your Highness," $9.5 million.
7. "Source Code," $9.1 million.
8. "Limitless," $5.7 million.
9. "Diary of a Wimpy Kid: Rodrick Rules," $4.9 million.
10. "The Lincoln Lawyer," $4.6 million.