"I tell the coward crusaders - I live in a place where you can't get to and kill me," he said. "I live in the hearts of millions."
One Libyan official claims Gadhafi and his family moved out of the compound some time ago.
Two NATO strikes could be heard early Friday morning, though it was not immediately clear what they targeted.
They followed a round of NATO airstrikes on Thursday that struck Libyan leader Moammar Gadhafi's compound in Tripoli. At least two people were killed.
NATO is facing complaints for an airstrike on the city of Brega that killed 11 Muslim clerics. But NATO officials say they choose their targets carefully, and the building that was hit had been identified as a command center.
The rebels have recently gotten major boosts from abroad, including $53 million in humanitarian aid from the U.S. Britain has promised to give them police gear.
A delegation of Libyan rebel fighters were meeting White House officials for talks on Friday.
The White House said Mahmoud Jibril, a representative of the Libyan Transitional National Council, would meet with senior administration officials, including National Security Adviser Tom Donilon, as well as members of Congress. But there were no plans for President Barack Obama to meet with Jibril and his delegation.
In the Hague, Netherlands, the prosecutor of the International Criminal Court said he would seek arrest warrants on Monday for three senior Libyan leaders for murder and persecution - with Gadhafi expected to be among them.
The Associated Press contributed to this story.
