The first three films have pocketed more than $2.5 billion worldwide, so expectations are riding high for the fourth film, led by a new director, Rob Marshall.
"People come in, you know, especially with a franchise of three, you don't want the fourth to be just another one in the show, in the series. You've got to go for something different," said McShane.
Another change was their location. For this film, the cast and crew dropped anchor in Hawaii.
"Shooting 'On Stranger Tides' was actually much more glamorous than the first three films," said Rush. "It was so spectacular because, you know, there are of course some CGI elements -- the mermaids and the fountain of youth -- but the rest of the film is like going back to the Golden Age when people starting making big spectacular sets in exotic locations."
Exotic locales and incredible costumes helped the actors become almost unrecognizable in their period looks.
Disney's "Pirates of the Caribbean: On Stranger Tides" opened in theaters Friday, May 20.
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