An average of 374,000 cars drive up and down the 405 every day, making it the most heavily traveled freeway in America.
It will be closed from the 10 to the 101 freeways.
See a live cam shot of the Mulholland Bridge construction site.
While transportation officials say this will create some serious traffic delays, a group of friends in Santa Monica have figured out a way to make this an opportunity to stay put and rediscover local businesses.
"Everything we saw was very doom and gloom, very stay at home, don't venture out," said Anastasia Roark, one of the site's founders. "We just really thought it would be really fun to put together an all-encompassing survival guide to help people get through it and find some silver lining to enjoy it."
Their website, car-mageddon.com, has taken off, with businesses jumping on board to promote the events they will be hosting on the weekend of the closure.
"Anyone who can come up with an idea to help local businesses I sign up right away," said Willy O'Sullivan, owner of O'Brien's Irish Pub & Restaurant in Santa Monica. "It's very good for the locals because we'll give them cheaper prices and it's very good for the local businesses because we getting the word out that we're still here."
The creators of the website are all friends and Westsiders.
They say they are donating a portion of the proceeds they've raised to a Santa Monica-based charity.
Beat Carmageddon with ABC7
The 405 shuts down the weekend of July 16-17, and ABC7 Eyewitness News is your home for the latest traffic news and information. Follow @abc7 and @BeatCarmageddon on Twitter, and use the hash tag #abc7traffic.
ABC7 has also partnered with Waze to help navigate the traffic. Download the Waze app, which provides free turn-by-turn GPS navigation based on the live conditions of the road. Join the community of drivers in Southern California today and beat Carmageddon.
