Kevin Antario Brown, 40, has pleaded not guilty to 22 felony sex counts. Brown is the son of the former leader of Bermuda.
Prosecutor Ann Marie Wise says witnesses will testify that Brown gave them unnecessary breast and pelvic checkups. In some cases, they had gone for treatment of ankle injuries or the flu.
The defense says the alleged crimes did not happen.
The alleged victims include an undercover vice officer and a 15-year-old girl.
Wise said Brown often flirted with his female patients, asked some of them out on dates and improperly touched them. One woman claims Brown raped her; another claims Brown slapped her rear end while she was bent over and asked, "Who's hittin' that?"
Wise said Brown's behavior came to a halt after an undercover vice officer, complaining of an ankle injury, visited Brown in June 2008 where the doctor lifted her shirt and bra and began fondling her breast. The incident was captured on an audio recorder, Wise said.
Brown, a family practitioner, has been acquitted twice in 2004 and 2006 of similar charges, Wise said.
Brown is the son of Ewart Brown, who stepped down as Bermuda's premier late last year.
Kevin Brown has been free on $4 million bail. He could face up to life in prison if convicted of all the charges.
The Associated Press contributed to this report.