The bodies were found about 6 a.m. Saturday in the 20400 block of Lassen Street by police acting on a tip.
At least one suspect has been named in the murders of the man and woman, who have not yet been identified.
Police said the suspect, 43-year-old Brent D. Zubek, lived on the property, but it was unclear what his relation was to the victims.
Investigators spent hours to track down the Zubek and even came close to capturing him around noon Sunday when undercover officers spotted him in Van Nuys driving in a black Ford F-150 pickup truck.
"The suspect was found in that vehicle," said Los Angeles Police Department Capt. Kris Pitcher. "Numerous hours later, the individual got into the vehicle, was driving away. He was surveyed in that vehicle. The vehicle was ultimately lost."
Pitcher said it was not a pursuit, but they did follow him until they lost him. They found the pickup truck abandoned about an hour later in a parking lot in Sherman Oaks.
Because the bodies are so badly decomposed, the coroner may not be able to identify the victims until next week.
Neighbors in the area said the home was once a childcare facility as well as an adult-care facility before going into foreclosure. Neighbors also said they saw people on the property after it went into foreclosure but didn't know if they were the new owners.
"We're overwhelmed and we're really still in shock," said Zubek's sister, Lisa Zubek, adding that she doesn't believe he committed the crime. "Hopefully he'll turn himself in and things will get sorted out in whatever direction that is."
Lisa Zubek said she didn't know he lived there.
Zubek was described as white, about 5-foot-11,185 pounds with short brown hair and blue eyes.
Police said the suspect is armed and dangerous.
Anyone with information related to the case is asked to call the LAPD at (877) 527-3247.