The woman was struck shortly after midnight on 50th Street East south of Avenue M.
Officers said the victim was walking down the street when the car hit her. The driver did not stop, and police have no witnesses.
Investigators said they are looking for a car that may have front-end damage.
If you have any information regarding this incident, you're urged to call the California Highway Patrol's Antelope Valley station at (661) 948-8566.