The collision between the fleeing 1997 Honda Accord and a Dodge Charger happened at Paseo Rancho Castilla and Mariondale Avenue about 1 a.m., according to the CHP.
The driver of the Honda was able to get out his car, but collapsed and died nearby, according to the CHP. His name was being withheld until his next of kin could be notified.
The CHP was trying to stop the driver for speeding.
Three people from the Dodge, all from Hayward, Calif., were taken to Los Angeles County-USC Medical Center. One person was reported to have major injuries, another with moderate injuries and the other with minor injuries, according to the CHP.
The pursuit started on the westbound 10 Freeway near Del Mar Avenue in Rosemead, with the Honda exiting at Fremont Avenue and continuing west on Hellman Avenue, according to the CHP.
The Dodge was struck at a stop sign at the entrance to California State University at Los Angeles. The car was reportedly knocked about 125 feet from the point of impact.
City News Service contributed to this report.