The singer announced Wednesday that she is launching the Born This Way Foundation, which is a nonprofit focusing on youth empowerment and "issues like self-confidence, well-being, anti-bullying, mentoring and career development."
Gaga's partners include the John D. and Catherine T. MacArthur Foundation, The California Endowment and the Berkman Center for Internet & Society at Harvard University.
The 25-year-old pop star and her mother, Cynthia Germanotta, will be directing the foundation.
"Together we hope to establish a standard of bravery and kindness, as well as a community worldwide that protects and nurtures others in the face of bullying and abandonment," Gaga said in a statement.
The Grammy-winning singer is known for speaking out for others. She recently said she wanted to meet with President Barack Obama to discuss her concerns over bullying, and she visited Maine last year to support the repeal of the military's "don't ask, don't tell" policy on gays.
In addition to multiple Grammy awards, the singer has released three platinum efforts - including her latest album, "Born This Way" - and has a massive online presence: The singer has over 15 million Twitter followers and 44 million Facebook fans.
The official launch for the Born This Way Foundation will be next year, and an advisory board will be announced soon.
The Associated Press contributed to this report.