Winfrey, 57, accepted the Jean Hersholt Humanitarian Award at the Academy of Motion Picture Arts and Sciences' third annual Governors Awards in Los Angeles.
Winfrey, a past Oscar nominee for "The Color Purple," was recognized for her support of educational initiatives and women's and children's issues around the world.
"For me, this Oscar will represent love from all of you," she said. "I thank you for your vote of love and I will use it to increase the open space in my heart to continue to do the great and good work that we've all come to do."
Jones received an honorary Oscar for his long film career. Sir Ben Kingsley presented Jones with the award in London's Wyndham Theater, where he is starring in "Driving Miss Daisy" with Vanessa Redgrave.
"I'm deeply honored, mighty grateful and just plain gobsmacked," the 80-year-old actor said.