The action tale took in $32 million. The movie recounts the legend of a mortal Greek peasant who is chosen by Zeus to lead a fight against a ruthless king.
Also opening this weekend was Adam Sandler's comedy, "Jack and Jill." It came in second with $26 million. Sandler plays dual roles in the movie, portraying a sturdy family man and his needy sister, who comes to visit for Thanksgiving.
The animated film "Puss in Boots," last week's winner, came in at No. 3.
"Tower Heist" and Leonard DiCaprio's "J. Edgar" tied to round out the top five with $13.2 million and 11.5 million, respectively.
The top 10 movies of the weekend were:
1. "Immortals," $32 million ($36 million international).
2. "Jack and Jill," $26 million ($2.7 million international).
3. "Puss in Boots," $25.5 million ($4.5 million
international).
4. "Tower Heist," $13.2 million ($7.6 million international).
5. "J. Edgar," $11.5 million.
6. "A Very Harold & Kumar 3D Christmas," $5.9 million.
7. "In Time," $4.2 million ($8.5 million international).
8. "Paranormal Activity 3," $3.6 million ($7.1 million
international).
9. "Footloose," $2.7 million.
10. "Real Steel," $2 million ($12 million international).
The Associated Press contributed to this report.
