One accuser testified that he screamed in vain for Dottie Sandusky to help him while her husband raped him in their basement.
The testimony raises the question of whether Sandusky's wife can be charged.
Experts say that evidence made public so far does not prove Dottie Sandusky did anything wrong, although prosecutors almost certainly are interested in talking to her.
She has said her husband is innocent of child sex abuse allegations.
Jerry Sandusky, 67, faces criminal accusations from 10 young men who claim he molested them when they were boys.
Penn State officials have been criticized for not doing enough to stop the alleged assaults. The scandal prompted the ouster of Hall of Fame football coach Joe Paterno and the school's longtime president, Graham Spanier.
The Sanduskys, who raised six adopted children together, have maintained that they would never do anything to hurt a child.
Jerry Sandusky said in media interviews that he showered and horsed around with boys but never sexually abused them.
He is out on bail and is due back in court next week.
The Associated Press contributed to this report.