Brees will appear on Thursday's episode of the educational children's TV show on PBS Kids.
The NFL star, who has two young sons, Baylen and Bowen, taped the segment, which co-stars the street's furry red resident, Elmo, before the start of this year's regular football season.
Brees leads the NFL with 4,368 passing yards, putting him on pace to break Dan Marino's single-season passing record of 5,084 yards, which has stood since 1984. He led the Saints to victory over the Indianapolis Colts in Super Bowl XLIV and was that game's MVP.
The Associated Press contributed to this report.