The Chinese Crested and Chihuahua mix, who won the 2011 World's Ugliest Dog contest, died in her sleep Saturday. She was 15 years old.
Yoda's striking looks made her famous. She appeared on national television.
The 1.8-pound pooch had lived a rough life before Terry Schumacher found her abandoned behind an apartment building and mistook her for a rat.
Yoda will keep the ugliest dog title until a new dog is crowned in June.
The Associated Press contributed to this report.