Sandusky's attorney Joe Amendola argued in a motion filed Thursday that the statute of limitations has expired for eight of the 10 alleged victims. In some cases, he says the charges aren't specific enough.
Amendola is also asking to delay the trial, scheduled to begin May 14. Such a pretrial motion is standard in Pennsylvania criminal cases.
"We raised a number of issues that we thought were pertinent for various reasons," said Amendola. "But the judge will have to decide that. We'll see what happens."
A spokesman for the state attorney general's office said the motion is under review, and prosecutors are planning to respond in writing within one week.
Sandusky, 68, has denied the allegations against him. He is confined to his home in State College while he awaits trial. He is accused of sexually abusing 10 boys over a 15-year period.
The case against Sandusky led to the firing of distinguished football coach Joe Paterno, who administrators said did not do enough once he learned about part of the allegations, and spawned criminal charges against two school officials.
In the motion, Amendola askes the judge to compel prosecutors to disclose the nature, times and locations of "any criminal offenses or acts of misconduct," beyond those for which he's been charged, if they plan to introduce them at trial.
The attorney also wants to be able to question prospective jurors individually and said jurors should be sequestered at trial because the case has received extensive publicity. He added it could take up to two weeks to pick a jury.
Amendola argues that a search of Sandusky's home in June was illegal and seeks to prevent prosecutors from using the material during the trial. That search yielded computers, records, CDs, DVDs, photos and other items.
The Associated Press contributed to this report.