The event, which lasts until 7 p.m. Wednesday, is for 19-year-old Miles Austrevich, who is battling a rare form of brain cancer. This is the fourth time that he's battled this cancer.
Next month, Austrevich will undergo a double stem cell transplant and will have to spend months in isolation to avoid infection.
Because laughter is the best medicine, comedians and average folks are telling clean one-liners at the Laugh Factory in Hollywood and Chicago so that Austrevich can watch from his hospital room.
"One of the first things that I thought was that we should start doing this for other kids," Austrevich said. "I know even know, people will go on the website, and they can benefit from the jokes even though they're personalized to me."
The goal is 10,000 jokes. Bob Saget and Paul Rodriguez appeared on stage to take part in the event on Tuesday night.
If you can't make it down to the Laugh Factory, you can still post a joke on www.Jokes4Miles.com.